![](https://wchsmo.org/wp-content/uploads/2024/02/44437_46546_2833_v150.jpg)
입센코리아(대표 오드리 슈바이처, Audrey SCHWEITZER)가 지난 3일 카보메틱스(제품명: Cabometyx, 성분명: 카보잔티닙, Cabozantinib) 국내 급여 5주년을 기념하여 신세포암 치료의 최신 지견에 대해 공유하는 자리를 가졌다고 7일 밝혔다.
고려의대 안산병원 박재영 교수가 좌장을 맡은 이번 행사는 한양대병원 조정기 교수의 ‘신세포암을 위한 최적의 치료 및 카보메틱스’ 발표에 이어, 세브란스병원 이승환 교수, 부산백병원 이찬호 교수, 서울아산병원 송채린 교수, 칠곡경북대병원 정재욱 교수가 전문가 토의에 참여해 카보메틱스의 신세포암 치료에 대한 임상적 의견과 경험을 공유했다.
한양대병원 조정기 교수는 신세포암의 최신 해외 가이드라인 업데이트 현황 소개에 이어 카보메틱스와 니볼루맙 3상 연구인 CheckMate-9ER 연구 주요 결과에 대해 발표했다.
2022년 3월, 카보메틱스와 니볼루맙 병용요법은 진행성 신장세포암 환자의 1차 치료제로 식약처 허가를 받았다. CheckMate 9ER 임상시험 결과에 따르면, 카보메틱스와 니볼루맙 병용요법 투여군의 무진행생존기간(PFS) 중앙값은 16.6개월로 수니티닙(Sunitinib) 투여군의 8.3개월 대비 2배 증가시켰다.
카보메틱스+니볼루맙 투여군은 수니티닙 투여군 대비 질병 진행 및 사망에 대한 위험률을 49% 유의하게 감소시켰으며(hazard ratio for disease progression or death, 0.51; 95% CI, 0.41 to 0.64; P<0.001) 객관적 반응률(ORR) 역시 카보메틱스+니볼루맙 투여군에서 57.7%로 수니티닙 투여군의 27.1% 대비 2배가량 우수한 것으로 나타났다(P<0.001). 또한 환자의 삶의 질 평가 항목에서도 카보메틱스+ 니볼루맙 투여군 환자들은 91주까지 모든 시점에서 수니티닙 투여군보다 더 나은 삶의 질을 보였다.
조 교수는 이어 환자 특성에 맞게 적절한 약제를 초기부터 사용하여 전체적인 생존률을 높이는 것의 중요함을 강조했다. METEOR 임상 하위그룹 분석 결과에 따르면 골 전이 환자에게서 무진행생존기간(PFS) 중앙값 7.4개월, HR=0.33 (95% Cl 0.21–0.51), 전체생존기간(OS) 20.1개월 HR=0.54 (95% CI, 0.34–0.84)로 신장세포암 2차 이상 단독 치료제로 카보메틱스의 골전이에 대한 효과를 설명하였다.
또한 CheckMate-9ER 하위 분석 결과에서도 골 전이 환자에게서 무진행생존기간(PFS) 중앙값 18 개월, HR=0.38 (95% Cl 0.25–0.59), 간전이 환자에게서 무진행생존기간(PFS) 중앙값 11 개월, HR=0.51 (95% Cl 0.33–0.79), 2개이상의 다중장기 전이 시 무진행생존기간(PFS) 중앙값 15 개월, HR=0.53 (95% Cl 0.43–0.67) 로 전이 환자에서 카보메틱스와 니볼루맙 병용 1차 치료로 효과가 입증되었음을 강조하였다.
이어진 전문가 토의에서는 신세포암 치료 시 티로신 키나아제 억제제 (Tyrosine kinase inhibitor)와 면역항암제 (check point inhibitor)의 병용요법 및 국내외 신세포암 치료에서 카보메틱스 사용 트렌드에 대한 열띤 토론이 진행됐다.
신세포암이 재발이 잦고 조기 진단이 어려운 질환인만큼, 되도록 조기 치료차수에서 효과적인 약제를 사용할 수 있는 치료환경 마련이 매우 중요한 질환라는 데 전문가들의 의견이 모아졌다.
특히 면역항암제와의 병용요법 등 다양하면서도 고무적인 임상결과들이 나오는 반면, 1차 면역항암제 치료 직후 2차 치료에서, 그리고 비투명세포암의 치료에서 카보메틱스의 급여혜택 적용이 필요하다는 지적이 이어졌다.
오드리 슈바이처(Audrey Schweitzer) 입센코리아 대표는 “오늘은 실제 임상 사례 공유를 통해 신세포암 치료 환경에서 카보메틱스의 임상적 가치를 재확인하는 자리였다”고 말하며, “앞으로도 카보메틱스가 전세계적으로 확보한 임상결과를 바탕으로 국내에서도 의료계 및 정부와 지속적으로 협력하여, 신세포암의 치료 수준을 높이고 환자를 위한 혁신에 대한 접근성을 높이기 위해 노력하겠다”고 덧붙였다.
A backlink pyramid offers numerous benefits for website owners and businesses.
It helps increase website visibility, traffic, and
search engine rankings. With a diversified portfolio of high-quality backlinks, the website gains credibility and
authority in its niche. Additionally, a backlink pyramid improves domain authority,
helping the site attract more organic traffic. It’s a powerful tool to boost online
presence and ultimately increase business revenue.
Buying Upwork reviews can provide several benefits for freelancers and employers alike.
For freelancers, having positive reviews can enhance their credibility and attract
more clients, leading to increased job opportunities and higher earnings.
Employers can also benefit from buying reviews as they can easily identify reliable and highly-rated freelancers for their projects, saving
time and effort in the hiring process. Overall, purchasing Upwork reviews can boost professional profiles and foster trust
between freelancers and employers.
A verified Coinbase account offers several advantages.
Firstly, it allows users to buy, sell, and store cryptocurrency
safely and securely. Verification also unlocks higher transaction limits, increasing your
purchasing power. Additionally, verified accounts gain access
to features like instant account funding, recurring buys,
and the ability to link a bank account. Don’t miss out on these benefits and
opt for a verified Coinbase account today!
Buying a verified Binance account comes with multiple benefits.
Firstly, it ensures hassle-free transactions as the account has
already gone through the verification process.
Additionally, it provides access to advanced trading features,
early access to new coin listings, and a higher trading limit.
Moreover, it enhances security by reducing the risk of unauthorized transactions.
Invest in a verified Binance account to streamline your crypto experience.
A verified Binance account offers numerous advantages to cryptocurrency traders.
It provides enhanced security, enabling users to protect their funds
and personal information. Verified accounts also allow higher withdrawal limits and prioritize
customer support. Additionally, it grants access to advanced trading features, leading to better
trading opportunities. Ensure legitimacy and convenience by purchasing
a verified Binance account.
Buying a verified Skrill account comes with several benefits.
Firstly, it provides a seamless and secure method of online payments.
Secondly, it allows users to easily deposit and withdraw funds
from various platforms. Thirdly, a verified account offers enhanced security features,
protecting against fraud and unauthorized access.
Lastly, it grants access to exclusive offers and promotions, making it an attractive choice for online shoppers
and businesses alike.
Buying TripAdvisor reviews may seem like a shortcut to boost your business’s reputation, but
the benefits are short-lived. Fake reviews can damage credibility and lead to distrust among customers.
Instead, focus on providing excellent service
and encouraging genuine reviews from satisfied customers.
This approach will build long-term trust and attract more customers organically.
Buying a Verified PayPal Account offers several benefits.
Firstly, it allows users to transact securely without sharing sensitive financial information. Moreover, it provides access to various online shopping platforms that exclusively
accept PayPal payments. Additionally, a verified account enables
international transactions and facilitates quick withdrawals
of funds. Overall, purchasing a Verified PayPal Account ensures convenience, safety, and expanded access to online shopping opportunities.
Buying a verified Bing Ads account can offer numerous benefits to businesses.
It provides instant access to Bing’s advertising platform and eliminates the hassle
of going through the verification process. This can save time and effort,
allowing businesses to focus on their marketing campaigns.
Additionally, a verified account enhances credibility and boosts ad performance
by unlocking special features and higher spending limits.
Don’t miss out on the advantages of a verified
Bing Ads account!
Buying Wikipedia backlinks can benefit your website in several ways.
Firstly, Wikipedia is one of the most authoritative websites on the internet, boosting your site’s credibility.
Secondly, it can drive targeted traffic as users often click on relevant links within Wikipedia articles.
Moreover, it enhances your site’s visibility in search engine results, improving your SEO efforts.
However, be cautious and ensure you purchase links from reputable sources to avoid potential penalties from Wikipedia.
Buying Fiverr reviews can provide several advantages.
Firstly, it helps build credibility and trust for
your business. Positive reviews attract potential customers
and increase conversion rates. Additionally, reviews provide valuable feedback, helping
you to improve your products or services.
It saves time too, as gathering genuine reviews can be time-consuming.
Overall, purchasing Fiverr reviews can boost your online reputation and give your business a competitive
edge.
Buying a verified Stripe account can greatly benefit online businesses.
It eliminates the hassle of going through the verification process and saves time.
A verified account allows for seamless payment processing, increasing customer trust and satisfaction. Additionally, it
opens up opportunities for international sales, as Stripe supports multiple currencies.
With a verified Stripe account, businesses can enjoy secure and smooth transactions, ultimately boosting profitability.
Buying an Amazon account can offer numerous benefits.
Firstly, users gain access to unlimited prime shipping services which
ensures speedy and cost-effective deliveries. Additionally, an Amazon account allows
for seamless purchase of a wide range of products, saving time and effort.
Lastly, it opens up a plethora of offers, discounts, and exclusive deals.
Buying an Amazon account is a worthwhile investment
for those seeking convenience and savings.
Buying android app reviews can greatly benefit app developers and businesses.
Positive reviews increase the visibility and credibility
of an app, attracting more downloads and users.
They also improve app store rankings and boost organic growth.
Additionally, these reviews provide valuable feedback, allowing developers to
enhance their app’s performance and user experience. Investing in android app reviews can be a smart strategy for app developers to
stand out in the competitive marketplace.
Buying dofollow backlinks can greatly benefit your website’s search engine optimization (SEO) efforts.
These backlinks not only enhance your site’s credibility and
authority but also drive organic traffic. They improve your website’s
visibility in search engine rankings, resulting in higher organic
search results. By purchasing these backlinks, you can save
time and effort spent on manual link building, allowing
you to focus on other crucial aspects of your business.
Overall, investing in dofollow backlinks can significantly boost your website’s online presence
and lead to increased traffic and conversions.
SiteJabber Reviews provides a plethora of benefits for online shoppers.
With over millions of reviews on various websites, it enables
users to make informed decisions while purchasing products or
services. From avoiding scams to finding reputable sellers, SiteJabber ensures a safe and reliable shopping experience.
Don’t miss out on the chance to make smarter choices and save your hard-earned money with SiteJabber
Reviews.
Buying Zillow reviews can greatly benefit both real estate agents and potential buyers.
Positive reviews increase agent visibility
and credibility, attracting more clients. Buyers gain insight into an agent’s competence
and professionalism through honest feedback.
Investing in reliable Zillow reviews helps navigate the
real estate market with confidence and ease.